His earliest credit is the 2002 film The Year That Trembled, where he was part of the transportation department. Later, Cofrancesco was a transcriber for reality television series and worked under various positions for short film projects, primarily as an intern.
Cofrancesco's first animated production was Danny Phantom, working as a production assistant during its three year run (2004 to 2007). He coordinated production on Dora the Explorer and was script coordinator on The Mighty B!.
In 2009, he joined the Family Guy staff as production coordinator. He was promoted to production supervisor in 2014, a position Cofrancesco maintained until leaving the series in 2018. He worked as a production manager on the direct-to-video film Curious George: Royal Monkey (2019).
Outside of the entertainment industry, Cofrancesco once co-owned a pie delivery shop with his wife Emily, called "I Heart Pies."